SCHIZOSTATIN, A POTENT SQUALENE SYNTHASE INHIBITOR FROM SCHIZOPHYLLUM-COMMUNE - ISOLATION, STRUCTURE ELUCIDATION, AND TOTAL SYNTHESIS

Authors
TANIMOTO T TSUJITA Y HAMANO K HARUYAMA H KINOSHITA T HOSOYA T KANEKO S TAGO K KOGEN H
Citation
T. Tanimoto et al., SCHIZOSTATIN, A POTENT SQUALENE SYNTHASE INHIBITOR FROM SCHIZOPHYLLUM-COMMUNE - ISOLATION, STRUCTURE ELUCIDATION, AND TOTAL SYNTHESIS, Tetrahedron letters, 36(35), 1995, pp. 6301-6304
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
35
Year of publication
1995
Pages
6301 - 6304
Database
ISI
SICI code
0040-4039(1995)36:35<6301:SAPSSI>2.0.ZU;2-6
Abstract
The novel schizostatin (1) has been isolated as a potent inhibitor of squalene synthase. Its structure elucidation and total synthesis are d escribed. Synthesis of the Z-isomer 12 and its biological activity are also reported.