SYNTHESIS OF FUNCTIONALIZED 2'-C-BRANCHED NUCLEOSIDES VIA THEIR GAMMA-BUTYROLACTONES

Functionalised 2'-C-branched nucleosides that contain either a carboxy lic acid (2), a primary amide (3) or a primary hydroxyl (4) group have been prepared and their protection for oligonucleotide synthesis inve stigated. The 2'-C-3'-O-gamma-butyrolactone (5) was also shown to be a useful intermediate for the preparation of these analogues.