Twenty-eight patients, all of whom developed multiple sclerosis before
16 years nf noe and all from a well-defined geographical population (
Grampian, north-eastern Scotland) were retrospectively studied. Age at
presentation, presenting features and interval between first and seco
nd attacks are discussed. Follow-up ranged from three to 47 years and
adult categorisation was applied to outcome. This suggested that on th
e whole, childhood-onset multiple sclerosis is a less aggressive disea
se than its adult counterpart.