Dma. Mann et al., THE EXTENT OF AMYLOID DEPOSITION IN BRAIN IN PATIENTS WITH DOWNS-SYNDROME DOES NOT DEPEND UPON THE APOLIPOPROTEIN-E GENOTYPE, Neuroscience letters, 196(1-2), 1995, pp. 105-108
The extent of deposition of amyloid beta protein (A beta) was investig
ated in 20 elderly patients with Down's syndrome, using the end-specif
ic monoclonal antibodies BC05 and BA27 to detect the presence of A bet
a(42(43)) and A beta(40) (respectively), and related to apolipoprotein
E (ApoE) genotype. No significant differences in the amount of A beta
deposited in the brain, either as A beta(42(43)) or A beta(40), were
noted in patients possessing an ApoE E4 allele, compared to those with
out. Patients with an ApoE E4 allele in general died at an earlier age
than those with only ApoE E3 alleles, the latter in turn being outliv
ed by those with an ApoE E2 allele. In Down's syndrome therefore, ApoE
may influence the timing of onset, or the rate of progression, of dis
ease but without affecting the type or total amount of pathology accum
ulated.