THE EXTENT OF AMYLOID DEPOSITION IN BRAIN IN PATIENTS WITH DOWNS-SYNDROME DOES NOT DEPEND UPON THE APOLIPOPROTEIN-E GENOTYPE

Citation
Dma. Mann et al., THE EXTENT OF AMYLOID DEPOSITION IN BRAIN IN PATIENTS WITH DOWNS-SYNDROME DOES NOT DEPEND UPON THE APOLIPOPROTEIN-E GENOTYPE, Neuroscience letters, 196(1-2), 1995, pp. 105-108
Citations number
33
Categorie Soggetti
Neurosciences
Journal title
ISSN journal
03043940
Volume
196
Issue
1-2
Year of publication
1995
Pages
105 - 108
Database
ISI
SICI code
0304-3940(1995)196:1-2<105:TEOADI>2.0.ZU;2-9
Abstract
The extent of deposition of amyloid beta protein (A beta) was investig ated in 20 elderly patients with Down's syndrome, using the end-specif ic monoclonal antibodies BC05 and BA27 to detect the presence of A bet a(42(43)) and A beta(40) (respectively), and related to apolipoprotein E (ApoE) genotype. No significant differences in the amount of A beta deposited in the brain, either as A beta(42(43)) or A beta(40), were noted in patients possessing an ApoE E4 allele, compared to those with out. Patients with an ApoE E4 allele in general died at an earlier age than those with only ApoE E3 alleles, the latter in turn being outliv ed by those with an ApoE E2 allele. In Down's syndrome therefore, ApoE may influence the timing of onset, or the rate of progression, of dis ease but without affecting the type or total amount of pathology accum ulated.