CHRONIC TREATMENT WITH THIOCTIC ACID DOES NOT PROTECT AGAINST MALONATE TOXICITY IN-VIVO

Authors
ANGEL R GREENAMYRE JT
Citation
R. Angel et Jt. Greenamyre, CHRONIC TREATMENT WITH THIOCTIC ACID DOES NOT PROTECT AGAINST MALONATE TOXICITY IN-VIVO, Neuroscience letters, 196(1-2), 1995, pp. 125-127
Citations number
13
Categorie Soggetti
Neurosciences
Journal title
Neuroscience letters → ACNP
ISSN journal
03043940
Volume
196
Issue
1-2
Year of publication
1995
Pages
125 - 127
Database
ISI
SICI code
0304-3940(1995)196:1-2<125:CTWTAD>2.0.ZU;2-2
Abstract
We reported previously that short-term systemic pretreatment with thio ctic acid is protective against NMDA and malonate lesions of the stria tum. In the current study, we examined the effects of 3 weeks of pretr eatment with various doses of thioctic acid (5-60 mg/kg per day) on ma lonate-induced striatal degeneration in adult rats. Tn this paradigm, we were unable to demonstrate protection against malonate toxicity. Th e reasons for the difference in efficacy between subacute and chronic treatment remain to be defined.