CATALYTIC ASYMMETRIC ADDITION-REACTION OF DIALKYLZINC TO NITRONE UTILIZING TARTARIC ACID ESTER AS A CHIRAL AUXILIARY

Authors
UKAJI Y SHIMIZU Y KENMOKU Y AHMED A INOMATA K
Citation
Y. Ukaji et al., CATALYTIC ASYMMETRIC ADDITION-REACTION OF DIALKYLZINC TO NITRONE UTILIZING TARTARIC ACID ESTER AS A CHIRAL AUXILIARY, Chemistry Letters, (1), 1997, pp. 59-60
Citations number
18
Categorie Soggetti
Chemistry
Journal title
Chemistry Letters → ACNP
ISSN journal
03667022
Issue
1
Year of publication
1997
Pages
59 - 60
Database
ISI
SICI code
0366-7022(1997):1<59:CAAODT>2.0.ZU;2-K
Abstract
The catalytic asymmetric addition reaction of dialkylzinc to carbon-ni trogen double bond in 3,4-dihydroisoquinoline N-oxide derivatives was achieved by utilizing a catalytic amount of dicyclopentyl (R,R)-tartra te to afford the corresponding (S)-hydroxylamines in high optical yiel ds up to 94% ee.