HYDROPHOBILIZATION OF LYSOZYME BY GENETIC COMBINATION WITH POLYPROLINE AT THE CARBOXYL-TERMINAL

Authors
ITO Y HAMAMATSU N KWON OH UEDA M TANAKA A IMANISHI Y
Citation
Y. Ito et al., HYDROPHOBILIZATION OF LYSOZYME BY GENETIC COMBINATION WITH POLYPROLINE AT THE CARBOXYL-TERMINAL, Chemistry Letters, (1), 1997, pp. 65-66
Citations number
14
Categorie Soggetti
Chemistry
Journal title
Chemistry Letters → ACNP
ISSN journal
03667022
Issue
1
Year of publication
1997
Pages
65 - 66
Database
ISI
SICI code
0366-7022(1997):1<65:HOLBGC>2.0.ZU;2-D
Abstract
Polyproline, which is an amphiphilic polypeptide, was incorporated int o lysozyme by the recombinant DNA technique. The hydrophobicity of lys ozyme increased with the incorporation of a longer polyproline. The ba ctericidal activity of lysozyme against Gram-negative bacteria increas ed with the hydrophobicity of the enzyme.