LEUKOCYTE-DERIVED NEUTROPHIL CHEMOTACTIC FACTOR-II PRODUCED BY INFILTRATED LEUKOCYTES IN ALLERGIC INFLAMMATION MODEL IN RATS IS MACROPHAGE INFLAMMATORY PROTEIN-2
J. Tanabe et al., LEUKOCYTE-DERIVED NEUTROPHIL CHEMOTACTIC FACTOR-II PRODUCED BY INFILTRATED LEUKOCYTES IN ALLERGIC INFLAMMATION MODEL IN RATS IS MACROPHAGE INFLAMMATORY PROTEIN-2, Immunological investigations, 24(5), 1995, pp. 757-764
In the air pouch-type allergic inflammation model in rats, leukocytes
collected from the pouch fluid 4 h after the antigen challenge produce
d proteinaceous chemotactic factors for neutrophils, The leukocytes fr
om the immunized rats produced significantly higher amount of the chem
otactic factors than that from the non-immunized rats. The major chemo
tactic factor, leukocyte-derived neutrophil chemotactic factor (LDNCF)
-2, was purified and found to be identical with rat macrophage inflamm
atory protein (MIP)-2 by N-terminal amino acid sequence analysis. Expr
ession of MIP-2 mRNA was higher in the leukocytes from the immunized r
ats than that from the non-immunized rats. Possible roles of LDNCF-2 (
MIP-2) in neutrophil infiltration in the allergic inflammation is disc
ussed.