N2S2 TETRADENTATE LIGANDS FOR SOFT CATIONIC SPECIES - PREPARATION OF NEW LIGANDS OF POTENTIAL INTEREST IN NUCLEAR-MEDICINE

The synthesis of N2S2 tetradentate ligands of the bis-(enaminothioeste r) type was carried out starting from 3-(methylthio)-3H-1,2-dithiolyli um iodides and diamines. The title compounds, which are potential liga nds for soft cationic species, can be obtained from 1,3 diaminopropan- 2-ol and subsequently modified into the dissymmetrical succinic acid e ster of the ligand and N-hydroxysuccinimide. The appendage of such a l inking group on the chelating structure should allow further grafting to monoclonal antibodies in view of potential applications in nuclear medicine.