M. Welcker et K. Helmke, THERAPY OF AUTOIMMUNE NEPHROTIC GLOMERULO PATHIES BY COMBINED IMMUNOADSORPTION AND IVIG THERAPY, Immunitat und Infektion, 23(4), 1995, pp. 140-141
Meanwhile more than 270 immunoadsorptions have been performed. 7 patie
nts with SLE and glomerulonephritis as well as 3 patients suffering fr
om Wegener's vasculitis and glomerulonephritis had been treated with c
ombined immunoadsorption and IVIG therapy. After three sessions of imm
unoadsorption (2-3 1 plasma filtrate) the patients received 10 g 7S-im
munoglobulin infusions on three consecutive days. Patients with SLE an
d end-stage kidney involvement (2 patients) did not show any benefit b
y the above mentioned treatment regimen. Patients with Wegener's vascu
litis and glomerulonephritis showed no significant improvement, except
in one of three patients who showed a remarkable decrease in proteinu
ria. On the other hand, patients with SLE and >>moderate<< kidney invo
lvement (short course of disease, no fixed structural changes) showed
improvement on combined immunoadsorption and IVIG therapy.