This paper highlights the bias in returns to scale or price-cost marku
p coefficients when estimated from the inverse of a production relatio
nship. Coefficients estimated from the inverse are larger than when es
timated directly, and the size of the bias increases as the price-cost
markup or the scale elasticity of the underlying production function
gets smaller. An instrumental variables estimator, although consistent
, still exhibits a small sample bias if more than one instrument is us
ed. For comparison, direct estimates of scale elasticities are provide
d for two-digit SIC private business sectors and for four-digit manufa
cturing sectors. Little evidence is found for increasing returns to sc
ale in the manufacturing sector.