AGED RATS ARE STILL RESPONSIVE TO THE ANTIDEPRESSANT AND MEMORY-IMPROVING EFFECTS OF OXYTOCIN

Authors
ARLETTI R BENELLI A POGGIOLI R LUPPI P MENOZZI B BERTOLINI A
Citation
R. Arletti et al., AGED RATS ARE STILL RESPONSIVE TO THE ANTIDEPRESSANT AND MEMORY-IMPROVING EFFECTS OF OXYTOCIN, Neuropeptides, 29(3), 1995, pp. 177-182
Citations number
72
Categorie Soggetti
Neurosciences,"Endocrynology & Metabolism
Journal title
Neuropeptides → ACNP
ISSN journal
01434179
Volume
29
Issue
3
Year of publication
1995
Pages
177 - 182
Database
ISI
SICI code
0143-4179(1995)29:3<177:ARASRT>2.0.ZU;2-F
Abstract
Oxytocin, intraperitoneally injected to 26-month-old male rats 60 min before testing, significantly improved social memory (at doses of 3 an d 6 ng/kg) and reduced the duration of immobility in the behavioral de spair test (at doses of 50 and 500 mu g/kg). These results are in agre ement with previous data obtained in adult rats and indicate that agin g does not compromise the social memory improving and antidepressant-l ike activities of oxytocin.