Surveillance for a second primary colon or rectal cancer, detection an
d treatment of recurrent disease, and health maintenance are the essen
tial components of follow-up of a patient population with potentially
curative resection of a primary large bowel cancer. The value of follo
w-up programs have been extensively studied with colorectal cancer. Of
100 colorectal cancer patients in a follow-up program, approximately
20 patients should have prolongation of life as a result of surveillan
ce, detection and treatment, and health maintenance. Detection of recu
rrent cancer and its treatment may be the most expensive and least eff
ective part of the follow-up program. Lead time is minimal with intens
ive follow-up (including serial CEA blood tests) when compared to the
time of diagnosis derived from symptoms of recurrent malignancy in an
informed patient. Aggressive reoperative surgery in selected patients
with recurrent disease with use of adjunctive radiation therapy and ch
emotherapy when appropriate, will salvage long term the greatest numbe
r of people and yield some palliative benefits. It is crucial that reo
perative surgery be pursued by an experienced team familiar with this
type of intervention. Comprehensive follow-up of colorectal cancer pat
ients has a high value in its medical economic cost and should continu
e to be pursued, studied, to become more cost effective, and integrate
d into a complete management plan.