PROGNOSTIC FACTORS FOR SURVIVAL AND DISEASE-FREE SURVIVAL IN HEPATIC METASTASES FROM COLORECTAL-CANCER TREATED BY RESECTION

The prognostic factors of 219 patients submitted to no hepatic resecti on for colorectal metastases have been statistically analyzed. The ove rall B-year actuarial survival rate was 24% and the 5-year disease-fre e survival rate was 18%. At univariate analysis four variables resulte d significant: 1) The stage of primary colorectal cancer: if the meser entic lymphnodes were metastatic (Dukes C) or uninvolved (Dukes B) B-y ear survival was respectively 16 and 38% (p<0.001). 2) The percentage of hepatic replacement: the B-year survival rate of patients with H1 ( <25%), H2 (25-50%) and H3 (>50%) was 27, 16 and 8% respectively (p<0.0 01). 3) The number of metastases: the 5-year survival of patients with 1, 2-3, >3 hepatic nodules was 29, 21 and 17% respectively (p<0.05). 4) The extent of surgical resection: 5-year survival after minor and m ajor resection was 28 and 18% respectively (p<0.05). At multivariate a nalysis only stage of primary and percentage of hepatic replacement re tained statistical significance. In 60% of 154 patients with recurrent disease the liver was again involved.