We report on the noise cancellation performance of several whole-corte
x MEG systems operated under diverse noise conditions, ranging from un
shielded environments to moderately shielded rooms. The noise cancella
tion is performed by means of spatial filtering using high order gradi
ometers (2nd or 3rd), which can be formed optionally either by SQUID e
lectronics firmware or by software. The spatial dependence of the grad
iometer responses was measured in an unshielded environment and compar
ed with simulations to yield an estimate of the system common mode mag
nitudes relative to field, 1st, and 2nd gradients. High order gradiome
ters were also formed when the system was operated in moderately shiel
ded rooms. The combination of the spatial filtering and room shielding
resulted in very high combined noise rejections approaching that of h
igh quality shielded rooms. Examples of noise cancellation under vario
us conditions will be shown.