SONOGRAPHIC AND BIOCHEMICAL PARAMETERS OF HEPATIC AND SPLENIC AFFECTIONS IN PATIENTS WITH APLASTIC-ANEMIA

Sonography of the liver, gallbladder, portal and splenic veins, bioche mical hepatic tests were conducted in 35 patients with aplastic anemia (AA). The patients were ill from 3 months to 20 years. Depending on A A, duration some patients displayed a small enlargement of the liver, changes in its echostructure, increased calibre of the portal veins. M oderate hepatomegaly was associated with biochemical shifts reflecting dysfunction of hepatic tissue. The above sonographic and biochemical changes observed usually in toxic hepatitis result from different chem ical compounds produced within AA genesis, from administration of anab olic hormones and other drugs, frequent transfusion of red cells and o ther blood components. The size of the, spleen was not changed, though its echo pattern was abnormal.