PULSE AND GAMMA-RADIOLYTIC STUDIES OF THE RADIOSENSITIZER SANAZOLE (AK-2123) IN PRESENCE OF URACIL

Authors
MATHEW R KAPOOR S NAIR CKK SASTRY MS HUILGOL NG GOPINATHAN C SINGH BB KAGIYA VT
Citation
R. Mathew et al., PULSE AND GAMMA-RADIOLYTIC STUDIES OF THE RADIOSENSITIZER SANAZOLE (AK-2123) IN PRESENCE OF URACIL, Radiation physics and chemistry, 49(2), 1997, pp. 233-235
Citations number
10
Categorie Soggetti
Nuclear Sciences & Tecnology","Chemistry Physical","Physics, Atomic, Molecular & Chemical
Journal title
Radiation physics and chemistry → ACNP
ISSN journal
0969806X
Volume
49
Issue
2
Year of publication
1997
Pages
233 - 235
Database
ISI
SICI code
0969-806X(1997)49:2<233:PAGSOT>2.0.ZU;2-D
Abstract
Radiolytic studies on sanazole, an effecient hypoxic cell radiosensiti zer generally referred to as AK-2123, revealed that its reactions with e(aq)(-) and OH radicals yield transients with lambda(max) at 295 and 290 nm and their respective bi-molecular rate constants are 3.6 x 10( 10) dm(3) mol(-1) s(-1) and 1.55 x 10(8) dm(3) mol(-1) s(-1). Prelimin ary studies on steady state gamma radiolysis of the drug in presence o f uracil indicate electron transfer from the pyrimidine base to AK-212 3. Copyright (C) 1997 Elsevier Science Ltd