PHOTOTOXIC AND PHOTOPROTECTIVE EFFECTS OF TOPICAL ISOTHIPENDYL

Authors
MOREAU A DOMPMARTIN A DUBREUIL A LEROY D
Citation
A. Moreau et al., PHOTOTOXIC AND PHOTOPROTECTIVE EFFECTS OF TOPICAL ISOTHIPENDYL, Photodermatology, photoimmunology & photomedicine, 11(2), 1995, pp. 50-54
Citations number
NO
Categorie Soggetti
Dermatology & Venereal Diseases
Journal title
Photodermatology, photoimmunology & photomedicine → ACNP
ISSN journal
09054383
Volume
11
Issue
2
Year of publication
1995
Pages
50 - 54
Database
ISI
SICI code
0905-4383(1995)11:2<50:PAPEOT>2.0.ZU;2-D
Abstract
Isothipendyl, an H1-receptor antagonist, is an antihistamince used as an antiallergic drug. Its molecular structure is close to the phenothi azines, but it has different photobiological properties. Like phenothi azines, isothipendyl is phototoxic with ultraviolet A (UVA) but it red uces the erythema response to UVB radiation. Isothipendyl seems to hav e the same protective properties as a sunscreen because its UVB protec tive properties are effective only if the substance is applied prior t o exposure.