To investigate acute, irreversible effects of exposure to ozone and ot
her air pollutants, the authors examined daily death counts in relatio
n to air pollution levels in Mexico City during 1990-1992. When consid
ered singly in Poisson regression models accounting for periodic effec
ts, the rate ratio for total mortality associated with a 100-ppb incre
ment in 1-hour maximum ozone concentration was 1.024 (95% confidence i
nterval (Cl) 1.011-1.039). Measures of average ozone concentration wer
e somewhat more strongly related to mortality. The rate ratio was 1.02
4 (95% Cl 0.984-1.062) per 100 ppb for sulfur dioxide and 1.050 (95% C
l 1.030-1.067) per 100 mu g/m(3) for total suspended particulates. How
ever, when all three pollutants were considered simultaneously, only t
otal suspended particulates remained associated with mortality, indica
ting excess mortality of 6% per 100 mu g/m(3) (rate ratio = 1.058, 95%
Cl 1.033-1.083), consistent with observations in other cities in the
United States and Europe. The authors found no independent effect of o
zone, but it is difficult to attribute observed effects to a single po
llutant in light of the complexity and variability of the mixture to w
hich people are exposed. Nevertheless, particulate matter may be a use
ful indicator of the risk associated with ambient air pollution.