EFFECTIVE STRATEGY FOR THE SYNTHESIS OF PYRIDO[1',2(1) 1,2]IMIDAZO[5,4-C]ISOQUINOLINE SYSTEM/

Authors
CHAVIGNON O RAIHANE M DEPLAT P CHABARD JL GUEIFFIER A BLACHE Y DAUPHIN G TEULADE JC
Citation
O. Chavignon et al., EFFECTIVE STRATEGY FOR THE SYNTHESIS OF PYRIDO[1',2(1) 1,2]IMIDAZO[5,4-C]ISOQUINOLINE SYSTEM/, Heterocycles, 41(9), 1995, pp. 2019-2026
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Heterocycles → ACNP
ISSN journal
03855414
Volume
41
Issue
9
Year of publication
1995
Pages
2019 - 2026
Database
ISI
SICI code
0385-5414(1995)41:9<2019:ESFTSO>2.0.ZU;2-C
Abstract
Annulation of 3-aceta(benza)mido-2-phenylimidazo[1,2-a]pyridines (2a,b ) by phosphorus oxychloride results in the formation of pyridoimidazoi soquinolines (3a,b) as potent antileukemic structures. An alternative route for obtaining the isoquinoline framework was centered on the aza -Wittig reaction of iminophosphorane (4) with different isocyanates.