ENHANCEMENT EFFECT OF AN ANTI-ANGIOGENIC AGENT, TNP-470, ON HYPERTHERMIA-INDUCED GROWTH SUPPRESSION OF HUMAN ESOPHAGEAL AND GASTRIC CANCERSTRANSPLANTABLE TO NUDE-MICE

The effect of a combination of TNP-470 (AGM-1470, an anti-angiogenic a gent) and hyperthermia on tumor growth was examined using human esopha geal (ESO-2) and gastric (NSC-8) cancers transplantable to nude mice. TNP-470 alone at a dose of 30 mg/kg three times a week for 2 weeks was sufficient to obtain an antitumor effect. A combination of this dose of TNP-470 and 43 degrees C hyperthermia for 30 min inhibited tumor gr owth markedly in comparison with either treatment alone. It was consid ered that angiogenesis after hyperthermia was inhibited by TNP-470, an d then regrowth of the tumor cells was potently suppressed by I educti on of O-2 pressure, pH and nutrient supply in the tumor tissue.