IRON, INTRACELLULAR CALCIUM-ION, LIPID-PEROXIDATION AND CARCINO-GENESIS

Authors
ANGHILERI LJ
Citation
Lj. Anghileri, IRON, INTRACELLULAR CALCIUM-ION, LIPID-PEROXIDATION AND CARCINO-GENESIS, Anticancer research, 15(4), 1995, pp. 1395-1400
Citations number
84
Categorie Soggetti
Oncology
Journal title
Anticancer research → ACNP
ISSN journal
02507005
Volume
15
Issue
4
Year of publication
1995
Pages
1395 - 1400
Database
ISI
SICI code
0250-7005(1995)15:4<1395:IICLAC>2.0.ZU;2-H
Abstract
The evaluation of the accumulated experimental results on the action o f complexed iron on cells indicates that the provoked cell injury is r ather the consequence of an inhibition of the cytosolic Ca2+ concentra tion regulatory system than art effect of iron-induced lipid peroxidat ion. The role of the consequent intracellular ionic environment change in the preneoplastic and neoplastic transformation of the cell is dis cussed.