P. Morgavi et al., SENSITIZATION OF HUMAN GLIOBLASTOMA T98G CELLS TO VP16 AND VM26 BY HUMAN TUMOR-NECROSIS-FACTOR, Anticancer research, 15(4), 1995, pp. 1423-1428
The effect of Tumor Necrosis Factor (TNF) on VP16 or VM26 cytotoxicity
was studied in a human glioblastoma cell line T98G, which expresses T
NF-receptors. Although T98G cells did not produce TNF endogenously the
y were resistant to the cytolytic effect of TNF. T98G cells were also
moderately sensitive to the action of VP16 or VM26. TNF given at 1000
U/ml was able to increase the cell drug-sensitivity significantly. Thi
s effect was due to an increase in the VP 16-induced cleavable-complex
es by TNF. These findings suggest that TNF specifically sensitizes hum
an glioma T98G cells to the effects of VP16 of VM26.