Ca. Naranjo et al., ABUSE OF PRESCRIPTION AND LICIT PSYCHOACTIVE SUBSTANCES BY THE ELDERLY - ISSUES AND RECOMMENDATIONS, CNS DRUGS, 4(3), 1995, pp. 207-221
The abuse of prescription and over-the-counter psychoactive medication
s, tobacco, caffeine or alcohol (ethanol) by elderly adults is a clini
cal situation that many physicians encounter. The issues of diagnosis
and clinical presentation of drug abuse may differ in the elderly comp
ared with younger individuals, and physicians need to be aware of thes
e issues to ensure the most appropriate management of elderly patients
. Cognitive (e.g. memory loss), physical (e.g. falls) and behavioural
(e.g. depression, insomnia) changes may be signs of substance abuse in
elderly individuals. However, these signs may be misdiagnosed as bein
g due to aging. The quantity of the substance(s) used by elderly perso
ns may underestimate the frequency and severity of problems as, due to
altered pharmacokinetics and pharmacodynamics, the elderly are more s
ensitive to the effects of many; drugs. Hypnosedatives are among the m
ost commonly used psychotropic medications in the elderly and they hav
e a high potential for abuse. The elderly are very sensitive to the CN
S depressant effects of these drugs and, as a result, misuse (e.g. uni
ntentional overuse) can lead to dependence and abuse. There is limited
information on the abuse of opioid analgesics, but their misuse can r
esult in physical dependence. Although the prevalence of tobacco smoki
ng is relatively low among the elderly, older smokers tend to smoke mo
re and be more dependent on nicotine than their younger counterparts.
Quitting smoking in old age has significant health benefits, and incre
ased age has been found to be associated with an increased success in
achieving abstinence. Caffeine, consumed mainly in the form of tea, ma
y contribute to insomnia and complaints about sleep quality, especiall
y among the institutionalised elderly Ulcers, pancreatic cancer and os
teoporosis have been related to caffeine intake in some, but not all,
studies. Alcohol abuse, dependence and associated problems are less li
kely to be detected in the elderly because many of the diagnostic crit
eria (e.g. work-related problems) do not apply. Elderly patients in ac
ute alcohol withdrawal may require more careful management than younge
r ones. Prevention strategies for substance abuse range from the educa
tion of patients, physicians and other healthcare workers to monitorin
g, regulations and legislations by governments. Future research should
aim to improve the diagnosis and detection of substance abuse, and to
develop treatment and prevention programmes.