IN-VIVO POTENT ANTIMALARIAL 1,2,4-TRIOXANES - SYNTHESIS AND ACTIVITY OF 8-(ALPHA-ARYLVINYL)6,7,10-TRIOXASPIRO,[4,5]DECANES AND -(ALPHA-ARYLVINYL)-1,2,5-TRIOXASPIRO[5,5]UNDECANES AGAINST PLASMODIUM-BERGHEI IN MICE

Authors
SINGH C MISRA D SAXENA G CHANDRA S
Citation
C. Singh et al., IN-VIVO POTENT ANTIMALARIAL 1,2,4-TRIOXANES - SYNTHESIS AND ACTIVITY OF 8-(ALPHA-ARYLVINYL)6,7,10-TRIOXASPIRO,[4,5]DECANES AND -(ALPHA-ARYLVINYL)-1,2,5-TRIOXASPIRO[5,5]UNDECANES AGAINST PLASMODIUM-BERGHEI IN MICE, Bioorganic & medicinal chemistry letters, 5(17), 1995, pp. 1913-1916
Citations number
24
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
17
Year of publication
1995
Pages
1913 - 1916
Database
ISI
SICI code
0960-894X(1995)5:17<1913:IPA1-S>2.0.ZU;2-T
Abstract
Fourteen new trioxanes belonging to 6,7,10-trioxaspiro[4,5]decane and 1,2,5-trioxaspiro[5,5]undecane series have been synthesized and screen ed against Plesmodium berghei in mice. Several of these trioxanes show promising blood schizontocidal activity.