PURINE 2',3'-ACYCLONUCLEOSIDES - IMPROVED SYNTHESIS AND ANTIPARASITICACTIVITY

Authors
SUFRIN JR SPIESS AJ MARASCO CJ CROFT SL SNOWDON D YARDLEY V BACCHI CJ
Citation
Jr. Sufrin et al., PURINE 2',3'-ACYCLONUCLEOSIDES - IMPROVED SYNTHESIS AND ANTIPARASITICACTIVITY, Bioorganic & medicinal chemistry letters, 5(17), 1995, pp. 1961-1964
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
17
Year of publication
1995
Pages
1961 - 1964
Database
ISI
SICI code
0960-894X(1995)5:17<1961:P2-ISA>2.0.ZU;2-Q
Abstract
Synthesis of purine 2',3'-acyclonucleosides has been improved by using methanol as solvent for sequential oxidation/reduction reactions on p eriodate- and borohydride-bound resins. Several O-acetylated derivativ es of acyclic analogs prepared by this procedure have significant anti trypanosomal activity in vitro.