SYNTHESIS AND BIOLOGICAL-ACTIVITY OF J-104,118, A NOVEL, POTENT INHIBITOR OF SQUALENE SYNTHASE

Authors
IWASAWA Y HAYASHI M NOMOTO T SHIBATA J MITSUYA M HIROTA K YONEMOTO M KAMEI T MIURA K TOMIMOTO K
Citation
Y. Iwasawa et al., SYNTHESIS AND BIOLOGICAL-ACTIVITY OF J-104,118, A NOVEL, POTENT INHIBITOR OF SQUALENE SYNTHASE, Bioorganic & medicinal chemistry letters, 5(17), 1995, pp. 1989-1994
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
17
Year of publication
1995
Pages
1989 - 1994
Database
ISI
SICI code
0960-894X(1995)5:17<1989:SABOJA>2.0.ZU;2-1
Abstract
A new structural class of squalene synthase (SQS) inhibitor, J-104,118 , was developed by chemical modification of L-592,901, The absolute co nfiguration of J-104,118 was determined by X-ray crystal analysis. An oral dose of J-104,118 potently inhibited cholesterol synthesis in mic e.