NON-ISLET-CELL TUMOR-ASSOCIATED WITH HYPOGLYCEMIA IN A CHILD - SUCCESSFUL LONG-TERM THERAPY WITH GROWTH-HORMONE

Hypoglycemia occurred in a 2-year-old girl with neuroblastoma, Initial ly, growth hormone secretion was suppressed, and she had low levels of insulin-like growth factor (IGF)-I and IGF binding protein-3, but ele vated levels of large molecular weight IGF-II, We postulated that the pathogenesis of her hypoglycemia involved production of IGF-II by her neuroblastoma, leading to GH suppression and an abnormally elevated ra tio of IGF to IGF binding protein, She was successfully treated with g rowth hormone; treatment was associated with normalization of the grow th hormone-dependent growth factor levels and with euglycemia.