UNRELATED PERIPHERAL-BLOOD STEM-CELL TRANSPLANTATION FOR FANCONI-ANEMIA

The Brazilian unrelated bone marrow donor program began in 1993 and an unrelated matched donor was found for a Fanconi anemia patient withou t a sibling match, An 11-year-old female recipient received FTBI (6.0 Gy) and cyclophosphamide (40 mg/kg) as conditioning, The 41-year-old f emale unrelated donor received G-CSF at 5 mu g/kg x 5 days, and on day 6 and 7 post-mobilization, peripheral blood stem cells were harvested , Engraftment was seen on day 19 post-BMT and she remains alive and we ll on day 191+, This case supports the potential role of harvesting G- CSF-stimulated PBSC for unrelated bone marrow transplantation.