Objectives: The aim of this study was to evaluate the actual role of p
hysical examination of the liver in normal subjects and in cirrhotic p
atients, Methods: One hundred healthy subjects and 100 patients with l
iver cirrhosis underwent a physical and an ultrasonographic evaluation
of the liver by independent operators. Physical examination was perfo
rmed by means of percussion and palpation to determine total liver spa
n, liver span below the costal margin, and liver consistency, Total li
ver span, liver span below the costal margin and liver volume were als
o determined by means of ultrasonography. Results: The agreement betwe
en physical and ultrasonographic assessment of the liver span below th
e costal margin was poor in controls (chance corrected agreement index
= 0.13) and excellent in patients (chance corrected agreement index =
0.93). Physical and ultrasonographic total liver span were correlated
in patients with cirrhosis (r = 0.592) but not in controls (r = 0.205
). Echo-measured liver span significantly correlated with the actual v
olume of the organ in both groups, whereas physical liver span signifi
cantly correlated with liver volume in cirrhosis but not in controls.
The difference between actual liver volume and the value predicted by
liver span was large, The cirrhotic liver was slightly reduced in size
in comparison with that of healthy subjects and differed by an increa
se in consistency and a thickened edge. Conclusions: The bedside exami
nation of the liver does not provide any accurate information regardin
g the actual volume of the organ. Its major role remains to define the
characteristics of lower edge, mainly consistency, which may help in
clinical diagnosis, Liver volume proved to predict prognosis in patien
ts with cirrhosis, but its measurement needs quantitative, reproducibl
e methods, which can be obtained only by imaging techniques.