Tg. Reilly et al., LOW-DOSE FAMOTIDINE AND CIMETIDINE IN SINGLE POSTPRANDIAL DOSES - A PLACEBO-CONTROLLED COMPARATIVE-STUDY OF OVERNIGHT PH, Gut, 37(3), 1995, pp. 325-328
To investigate the relative abilities of low doses of famotidine and c
imetidine to raise intragastric pH after a single postprandial evening
dose, 16 healthy volunteers were recruited to a four period crossover
trial of famotidine 10 mg, cimetidine 100 mg and 200 mg compared with
placebo. Intragastric pH was monitored between 1800 and 0730 with a n
asogastric pH electrode. Median gastric pH rose from 1.35 (interquarti
le range 1.1-1.65) with placebo to 1.95 (1.6-5.35, p<0.001 Friedman ra
nk) after dosing with famotidine 10 mg, to 1.46 (1.3-2.0, 0.05<p<0.1)
after cimetidine 200 mg, and remained 1.35 (1.1-1.6, p>0.2) after cime
tidine 100 mg. Intragastric pH was above 3 for 34% (p<0.005) of the ti
me after dosing with famotidine, compared with 13.6% (p>0.2) after cim
etidine 200 mg, 9.5% (p>0.2) after cimetidine 100 mg, and 4.7% after p
lacebo. The rise of intragastric pH after famotidine 10 mg is signific
antly greater than that after either 200 mg or 100 mg cimetidine when
the drugs are used postprandially.