ANTITUMOR AND IMMUNOSUPPRESSIVE ACTIVITY OF MERBARONES ANALOGS AND ARYLIDENEHYDRAZINOPYRIMIDINES

The synthesis of Merbarone's analogues, the 4-thio- or 4-oxo derivativ es of bamoyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine is described, starting from ethyl-2-oxo-4-thioxo-1,2,3,4-tetrahydropyrimidine. That was also used as staring material for synthesis of NCS624947 analogue s, the 4-arylidenehydrazino-5-carbamoylpyrimidines. The reduction of a rylidenehydrazinopyrimidines with hydrogen on Pd/C was also performed. The obtained compounds were successfully tested for anticancer and im munomodulating activity.