SYNTHESIS OF ACYCLO C-NUCLEOSIDE ANALOGS - ITOL-1-YL)-1,2,4-TRIAZOLO[3,4-B]1,3,4-THIADIAZOLES AND ,4-BIS(1,2,4-TRIAZOLO[3,4-B]1,3,4-THIADIAZOL-6-YL) GALACTOTETRITOLS

Authors
SHABAN MAE NASR AZ TAHA MAM
Citation
Mae. Shaban et al., SYNTHESIS OF ACYCLO C-NUCLEOSIDE ANALOGS - ITOL-1-YL)-1,2,4-TRIAZOLO[3,4-B]1,3,4-THIADIAZOLES AND ,4-BIS(1,2,4-TRIAZOLO[3,4-B]1,3,4-THIADIAZOL-6-YL) GALACTOTETRITOLS, Die Pharmazie, 50(8), 1995, pp. 534-537
Citations number
24
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Die Pharmazie → ACNP
ISSN journal
00317144
Volume
50
Issue
8
Year of publication
1995
Pages
534 - 537
Database
ISI
SICI code
0031-7144(1995)50:8<534:SOACA->2.0.ZU;2-Y
Abstract
Reaction of 4-amino-3-aryl-1,2,4-triazol-5-thiols with 2,3,4,5,6-penta -O-acetyl-D-gluconic acid or 2,3,4,5-tetra-O-acetylgalactaric acid in the presence of phosphoryl chloride gave the corresponding -yl)-3-aryl -1,2,4-triazolo[3,4-b]1,3,4-thiadiazole or 3-aryl-1,2,4-triazolo[3,4-b ]1,3,4-thiadiazol-6-yl) galacto-tetritols, respectively which upon de- O-acetylation with methanolic ammonia or sodium ethoxide in ethanol ga ve the corresponding acyclo C-nucleosides.