We report two cases of acute epididymo-orchitis developing 4 to 6 week
s after cryoablation for prostate cancer, One patient required a simpl
e orchiectomy for epididymal abscess; the other responded to treatment
with antibiotics. Since the occurrence of these two cases, we routine
ly perform bilateral vasectomy prior to prostate cryoablation, We sugg
est that an extended course of prophylactic antibiotics may also be ne
eded in order to avoid this complication.