ALPHA(2)-ADRENOCEPTOR MEDIATED ANTIINFLAMMATORY ACTION OF NEW IMIDAZOLI(DI)NES AGAINST CARRAGEENAN-INDUCED RAT PAW EDEMA

Authors
VEERANJANEYULU A RAO CS MURALIDHAR N SRIDHAR N
Citation
A. Veeranjaneyulu et al., ALPHA(2)-ADRENOCEPTOR MEDIATED ANTIINFLAMMATORY ACTION OF NEW IMIDAZOLI(DI)NES AGAINST CARRAGEENAN-INDUCED RAT PAW EDEMA, Asia Pacific journal of pharmacology, 10(1), 1995, pp. 5-8
Citations number
NO
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Asia Pacific journal of pharmacology → ACNP
ISSN journal
02179687
Volume
10
Issue
1
Year of publication
1995
Pages
5 - 8
Database
ISI
SICI code
0217-9687(1995)10:1<5:AMAAON>2.0.ZU;2-#
Abstract
Newer clonidine analogs ST-93, ST-600, ST-375 and clonidine exhibited anti-inflammatory activity (Al) in carrageenin induced paw edema in ra ts. Clonidine showed maximum Al activity while ST-375 exhibited minimu m activity. All the agents retained their anti-carrageenin action in a drenalectomised rats. The Al effect of ST-93, ST-600, ST-375 and cloni dine was reversed by yohimbine. However, prazosin failed to block the Al activity of these analogs. The data suggests that the newer clonidi ne analogs possess Al activity mediated through activation of alpha(2) -adrenoceptors against carrageenin induced rat paw edema.