ANTIARRHYTHMICS BISARAMIL AND S-1389 INHIBIT GLIBENCLAMIDE-SENSITIVE K-ENCLOSED XENOPUS OOCYTES( CURRENTS IN FOLLICLE)

Effects of five class I novel antiarrhythmics on glibenclamide-sensiti ve Kf currents were investigated using follicle-enclosed Xenopus oocyt es. At a holding potential of -20 mV, bisaramil and S-1389 suppressed Y-26763-induced/glibenclamide-sensitive K+ currents with IC50 values o f 135 mu M and 167 mu M, respectively. Pentisomide, AN-132 and TYB-382 3 showed less potent inhibition.