ULTRAVIOLET-B IRRADIATION INCREASES ENDOTHELIN-1 AND ENDOTHELIN RECEPTOR EXPRESSION IN CULTURED HUMAN KERATINOCYTES

Authors
TSUBOI R SATO C OSHITA Y HAMA H SAKURAI T GOTO K OGAWA H
Citation
R. Tsuboi et al., ULTRAVIOLET-B IRRADIATION INCREASES ENDOTHELIN-1 AND ENDOTHELIN RECEPTOR EXPRESSION IN CULTURED HUMAN KERATINOCYTES, FEBS letters, 371(2), 1995, pp. 188-190
Citations number
32
Categorie Soggetti
Biophysics,Biology
Journal title
FEBS letters → ACNP
ISSN journal
00145793
Volume
371
Issue
2
Year of publication
1995
Pages
188 - 190
Database
ISI
SICI code
0014-5793(1995)371:2<188:UIIEAE>2.0.ZU;2-C
Abstract
The effect of ultraviolet B (UVB) irradiation on endothelin-l (ET-1) a nd ET receptor expression was examined using cultured normal human ker atinocytes. Keratinocytes secreted ET-1 in the medium at a level of 2. 1 pg/day/10(5) cells. UVB irradiation up to 10 mJ/cm(2) increased ET-I secretion 3-fold, and potentiated expression of mRNA for ET-1. Both E T(A) and ET(B) receptor mRNAs were detected in keratinocytes, and thei r expression was up-regulated by 5 mJ/cm(2) UVB irradiation.