R. Tsuboi et al., ULTRAVIOLET-B IRRADIATION INCREASES ENDOTHELIN-1 AND ENDOTHELIN RECEPTOR EXPRESSION IN CULTURED HUMAN KERATINOCYTES, FEBS letters, 371(2), 1995, pp. 188-190
The effect of ultraviolet B (UVB) irradiation on endothelin-l (ET-1) a
nd ET receptor expression was examined using cultured normal human ker
atinocytes. Keratinocytes secreted ET-1 in the medium at a level of 2.
1 pg/day/10(5) cells. UVB irradiation up to 10 mJ/cm(2) increased ET-I
secretion 3-fold, and potentiated expression of mRNA for ET-1. Both E
T(A) and ET(B) receptor mRNAs were detected in keratinocytes, and thei
r expression was up-regulated by 5 mJ/cm(2) UVB irradiation.