THE UTILITY OF CONTROLLED-RELEASE NORGESTOMET IMPLANTS IN SYNCHRONIZING ESTRUS AND DIAGNOSING PREGNANCY IN EWES, AND FACTORS AFFECTING THE DIFFUSION RATE OF NORGESTOMET FROM SILICONE IMPLANTS
Dj. Kesler et Rj. Favero, THE UTILITY OF CONTROLLED-RELEASE NORGESTOMET IMPLANTS IN SYNCHRONIZING ESTRUS AND DIAGNOSING PREGNANCY IN EWES, AND FACTORS AFFECTING THE DIFFUSION RATE OF NORGESTOMET FROM SILICONE IMPLANTS, Drug development and industrial pharmacy, 23(2), 1997, pp. 217-220
One hundred Suffolk and cross-bred ewes were implanted with norgestome
t/silicone implants to assess efficacy and utility, and to determine f
actors affecting norgestomet diffusion. The overall estrus and lambing
responses were 90% and 67%, respectively. Administration of the impla
nt for 14 days during pregnancy, in conjunction with progesterone dete
rmination on the 14th day, permitted the diagnosis of pregnancy status
with 100% accuracy. Norgestomet implantation had no adverse effects o
n established pregnancy. implants that were movable in situ on the 14t
h day had less connective tissue encapsulation and a higher (p < 0.05)
norgestomet diffusion rate than implants that had rigid subcutaneous
placement and more connective tissue encapsulation.