SYNAPTIC LIKE MICROVESICLES - DO THEY PARTICIPATE IN REGULATED EXOCYTOSIS

Authors
Citation
I. Llona, SYNAPTIC LIKE MICROVESICLES - DO THEY PARTICIPATE IN REGULATED EXOCYTOSIS, Neurochemistry international, 27(3), 1995, pp. 219-226
Citations number
83
Categorie Soggetti
Biology,Neurosciences
ISSN journal
01970186
Volume
27
Issue
3
Year of publication
1995
Pages
219 - 226
Database
ISI
SICI code
0197-0186(1995)27:3<219:SLM-DT>2.0.ZU;2-5
Abstract
Synaptic like microvesicles (SLMV) form a pleiomorphic population of v esicles present in neuroendocrine cells of the pituitary and the adren al medulla. Their composition and biogenesis is very similar to small synaptic vesicles (SSV) present in nerve terminals. Membrane proteins of SSV involved in fusion (synaptotagmin) and trafficking (Rab 3) toge ther with synaptophysin have been identified on SLMV. The SLMV from pa ncreatic beta cells store GABA, those present in chromaffin cells cate cholamines and/or acetylcholine. We conclude that SLMV may participate in regulated exocytosis based on (a) their localization near release sites, (b) their content and (c) their membrane composition. The funct ional meaning and the way this process is regulated remain to be eluci dated.