SYNTHESIS OF 7-MEMBERED, 8-MEMBERED AND 9-MEMBERED RINGS VIA ENDO HECK CYCLIZATIONS OF AMINO-ACID DERIVED SUBSTRATES

Authors
GIBSON SE MIDDLETON RJ
Citation
Se. Gibson et Rj. Middleton, SYNTHESIS OF 7-MEMBERED, 8-MEMBERED AND 9-MEMBERED RINGS VIA ENDO HECK CYCLIZATIONS OF AMINO-ACID DERIVED SUBSTRATES, Journal of the Chemical Society, Chemical Communications, (17), 1995, pp. 1743-1744
Citations number
26
Categorie Soggetti
Chemistry
Journal title
Journal of the Chemical Society, Chemical Communications → ACNP
ISSN journal
00224936
Issue
17
Year of publication
1995
Pages
1743 - 1744
Database
ISI
SICI code
0022-4936(1995):17<1743:SO78A9>2.0.ZU;2-B
Abstract
Aryl iodides tethered to dehydroalanine units by two to four methylene groups undergo intramolecular Heck reactions under anhydrous Jeffery conditions to give 7-, 8- and 9-membered rings by the endo-mode of cyc lisation; under harsher; conditions, a palladium intermediate formed b y the exo-mode of cyclisation is expressed as reduced products.