Se. Gibson et Rj. Middleton, SYNTHESIS OF 7-MEMBERED, 8-MEMBERED AND 9-MEMBERED RINGS VIA ENDO HECK CYCLIZATIONS OF AMINO-ACID DERIVED SUBSTRATES, Journal of the Chemical Society, Chemical Communications, (17), 1995, pp. 1743-1744
Aryl iodides tethered to dehydroalanine units by two to four methylene
groups undergo intramolecular Heck reactions under anhydrous Jeffery
conditions to give 7-, 8- and 9-membered rings by the endo-mode of cyc
lisation; under harsher; conditions, a palladium intermediate formed b
y the exo-mode of cyclisation is expressed as reduced products.