STEREOCHEMICAL STUDIES ON THE PROPOSED SPIRO INTERMEDIATE FOR THE BIOSYNTHESIS OF THE NATURAL PORPHYRINS - DETERMINATION BY A NOVEL X-RAY-METHOD OF THE ABSOLUTE-CONFIGURATION OF THE SPIROLACTAM WHICH INHIBITS COSYNTHETASE

Authors
SPIVEY AC CAPRETTA A FRAMPTON CS LEEPER FJ BATTERSBY AR
Citation
Ac. Spivey et al., STEREOCHEMICAL STUDIES ON THE PROPOSED SPIRO INTERMEDIATE FOR THE BIOSYNTHESIS OF THE NATURAL PORPHYRINS - DETERMINATION BY A NOVEL X-RAY-METHOD OF THE ABSOLUTE-CONFIGURATION OF THE SPIROLACTAM WHICH INHIBITS COSYNTHETASE, Journal of the Chemical Society, Chemical Communications, (17), 1995, pp. 1789-1790
Citations number
8
Categorie Soggetti
Chemistry
Journal title
Journal of the Chemical Society, Chemical Communications → ACNP
ISSN journal
00224936
Issue
17
Year of publication
1995
Pages
1789 - 1790
Database
ISI
SICI code
0022-4936(1995):17<1789:SSOTPS>2.0.ZU;2-E
Abstract
A novel X-ray analysis, combined with correlations by circular dichroi sm, has been used to establish the (R)-configuration at the stereocent re in that enantiomer of the spirolactam 4 which. strongly inhibits ur oporphyrinogen III synthase.