DIFUROCOUMARINS, PSORALEN ANALOGS - SYNTHESIS AND DNA PHOTOBINDING

Authors
CAFFIERI S MOOR ACE VANHENEGOUWEN GMJB DALLACQUA F GUIOTTO A CHILIN A RODIGHIERO P
Citation
S. Caffieri et al., DIFUROCOUMARINS, PSORALEN ANALOGS - SYNTHESIS AND DNA PHOTOBINDING, Zeitschrift fur Naturforschung. B, A journal of chemical sciences, 50(8), 1995, pp. 1257-1264
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear
Journal title
Zeitschrift fur Naturforschung. B, A journal of chemical sciences → ACNP
ISSN journal
09320776
Volume
50
Issue
8
Year of publication
1995
Pages
1257 - 1264
Database
ISI
SICI code
0932-0776(1995)50:8<1257:DPA-SA>2.0.ZU;2-3
Abstract
A new tetracyclic derivative, difurocoumarin, was synthesized and stud ied in order to ascertain its possible use as a photochemotherapeutic agent alternative to psoralens. The compound proved able to photobind monofunctionally to DNA on irradiation with UV-A. A photocycloadduct w ith thymine was isolated and characterized spectroscopically.