THE BTB POZ DOMAIN - A NEW PROTEIN-PROTEIN INTERACTION MOTIF COMMON TO DNA-BINDING AND ACTIN-BINDING PROTEINS/

The BTB/POZ domain defines a newly characterized protein-protein inter action interface. It is highly conserved throughout metazoan evolution and generally found at the Nn, terminus of either actin-binding or, m ore commonly, nuclear DNA-binding proteins. But mediating protein bind ing in large aggregates, the BTB/POZ domain serves to organize higher order macromolecular complexes involved in ring canal formation or chr omatin folding.