HIGH-DOSE CHEMOTHERAPY WITH AUTOLOGOUS BONE-MARROW TRANSPLANTATION FOR REFRACTORY METASTATIC GESTATIONAL TROPHOBLASTIC DISEASE

A patient with gestational trophoblastic disease failed to respond to all standard multiple-agent chemotherapy and had progressive uterine d isease. Total hysterectomy also proved ineffective. We therefore admin istered high-dose cyclophosphamide, etoposide, and melphalan with auto logous bone marrow support. Severe marrow suppression followed but a c omplete remission was achieved and the patient remains free of disease 3 years after the completion of therapy, This result seems to confirm the value of using high-dose multiagent therapy to optimize the dose- effect of therapy regimens on drug-refractory gestational trophoblasti c disease. (C) 1995 Academic Press, Inc.