PRIMARY NON-CLEAR-CELL ADENOCARCINOMAS OF THE VAGINA IN OLDER DES-EXPOSED WOMEN

The association between in utero diethylstilbestrol (DES) exposure and the development of clear-cell adenocarcinoma of the vagina and cervix has been well, described, However, non-clear-cell mucin-secreting ade nocarcinoma in women with DES exposure has not been previously reporte d. We present two cases of non-clear-cell mucinous adenocarcinoma in w omen having a history of in utero DES exposure. These cancers were fou nd in older women and were more advanced than the clear-cell adenocarc inoma associated with DES, Histologic features of these tumors were no table for atypical, irregular glands lined by endocervical, intestinal , and endometrioid epithelium. The development of non-clear-cell adeno carcinoma of the vagina in these patients may be associated with DES e xposure in utero, Long-term surveillance of DES-exposed women may be w arranted. (C) 1995 Academic Press, Inc.