TEL1, A GENE INVOLVED IN CONTROLLING TELOMERE LENGTH IN SACCHAROMYCES-CEREVISIAE, IS HOMOLOGOUS TO THE HUMAN ATAXIA-TELANGIECTASIA GENE

Authors
GREENWELL PW KRONMAL SL PORTER SE GASSENHUBER J OBERMAIER B PETES TD
Citation
Pw. Greenwell et al., TEL1, A GENE INVOLVED IN CONTROLLING TELOMERE LENGTH IN SACCHAROMYCES-CEREVISIAE, IS HOMOLOGOUS TO THE HUMAN ATAXIA-TELANGIECTASIA GENE, Cell, 82(5), 1995, pp. 823-829
Citations number
46
Categorie Soggetti
Biology,"Cell Biology
Journal title
Cell → ACNP
ISSN journal
00928674
Volume
82
Issue
5
Year of publication
1995
Pages
823 - 829
Database
ISI
SICI code
0092-8674(1995)82:5<823:TAGIIC>2.0.ZU;2-8
Abstract
Yeast chromosomes terminate in tracts of simple repetitive DNA (poly[G (1-3)T]). Mutations in the gene TEL1 result in shortened telomeres. Se quence analysis of TEL1 indicates that it encodes a very large (322 kD a) protein with amio acid motifs found in phosphatidylinositol/protein kinases. The closest homolog to TEL1 is the human ataxia telangiectas ia gene.