A PRELIMINARY EVALUATION OF HYDROXYUREA FOR THE TREATMENT OF RHEUMATOID-ARTHRITIS

Objective, To obtain preliminary evidence on the safety and efficacy o f low dose hydroxyurea as a treatment for rheumatoid arthritis (RA). M ethodr. Five patients with active RA unresponsive to conventional ther apy were entered into a 12 week, open label trial of hydroxyurea follo wed by a one month postdrug evaluation. Results. Three of the 4 patien ts completing the study had a decrease in morning stiffness and number of swollen and tender joints. All 4 patients had a decrease in pain a nd an increase in function as measured by a modified health assessment questionnaire. No patient had improvement in sedimentation rate, C-re active protein, or subjective measures of global well being, However, 3 of the 4 patients had disease flare after the drug was withdrawn, de monstrated by increased number of swollen and tender joints. Conclusio n. Low dose hydroxyurea may be effective in the treatment of RA, but c onfirmation will require further testing by a randomized double blind placebo controlled trial of patients with a broader spectrum of diseas e severity over a longer period of therapeutic intervention.