The prompt fragmentation of a very massive nuclear system obtained in
heavy-ion collisions at intermediate energies is studied in the framew
ork of the semi-classical Landau-Vlasov model taking into account the
two-body residual interactions and the isospin dependence. In a first
phase, compression and expansion take place. In a second stage, the st
rong Coulomb repulsion and neutron-proton asymmetry lead to the format
ion of an evanescent bubble-like configuration which decays rapidly in
to several fragments. Time evolution of the densities and energy compo
nents as well as dependence on the beam energy are particularly analyz
ed. Quantitative comparisons are made with experimental data obtained
in the Pb-208(29 MeV/u) + Au-197 reaction.