We have examined the spatial distribution of substructure in clusters
of galaxies using Einstein X-ray observations. Subclusters are found t
o have a markedly anisotropic distribution that reflects the surroundi
ng matter distribution on supercluster scales. Our results suggest a p
icture in which cluster formation proceeds by mergers of subclusters a
long large-scale filaments. The implications of such an anisotropic fo
rmation process for the shapes, orientations, and kinematics of cluste
rs are discussed briefly.