ADDITIVITY TEST FOR COMPOSITION OF BINOMIAL EFFECTS IN CHROMOSOME-ABERRATIONS AFTER RADIATION-INJURY

Authors
KOMORNIK J MIKULECKY M BENO M
Citation
J. Komornik et al., ADDITIVITY TEST FOR COMPOSITION OF BINOMIAL EFFECTS IN CHROMOSOME-ABERRATIONS AFTER RADIATION-INJURY, Statistics in medicine, 14(17), 1995, pp. 1941-1947
Citations number
7
Categorie Soggetti
Statistic & Probability","Medicine, Research & Experimental","Public, Environmental & Occupation Heath","Statistic & Probability
Journal title
Statistics in medicine → ACNP
ISSN journal
02776715
Volume
14
Issue
17
Year of publication
1995
Pages
1941 - 1947
Database
ISI
SICI code
0277-6715(1995)14:17<1941:ATFCOB>2.0.ZU;2-I
Abstract
Additivity of clastogenic effects of two doses of radiation to human p eripheral blood lymphocytes is considered, We compare the effects of c ombined tritium and gamma irradiation with the sum of the effects of e ither irradiation administered separately. Our solution is based on co mbination of de Moivre and Cramer-Slucky theorems. The results for 14 subjects where the deletion types of chromosome aberrations were count ed indicate a Normal distribution of the sample additivity index, osci llating non-significantly around zero, with one outlier towards adapti vity and another towards synergism of the effect of the two doses abso rbed by the cells.